When a single 100 mg dose of Vigorex was administered with erythromycin, a specific CYP3A4 inhibitor, at steady state (500 mg bid for 5 days), there was a 182% increase in Vigorex systemic exposure (AUC).
increase in Vigorex Cmax and a 210% increase in Vigorex AUC. Vigorex had no drugs. Vigorex has systemic vasodilatory properties and may augment the
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In another study in healthy male volunteers, coadministration with the HIV protease inhibitor ritonavir, which is a highly potent P450 inhibitor, at steady state (500 mg bid) with Vigorex (100 mg single dose) resulted in a 300% (4-fold) increase in Vigorex Cmax and a 1000% (11-fold) increase in Vigorex plasma AUC. At 24 hours the plasma levels
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210% increase in Vigorex AUC. Vigorex had no effect on saquinavir In a separate drug interaction study, when amlodipine, 5 mg or 10 mg, and Vigorex
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