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Author: Admin | 2025-04-28
SCIENTIFIC ARTICLE: PDF OnlyArterial and Venous Dilation by Nitroprusside and Nitroglycerin—Is There a Difference?Gerson, John I. MD*; Allen, Forrest B. MD*; Seltzer, Joseph L. MD†; Parker, Frederick B. Jr. MD‡; Markowitz, Alan H. MD§ * Assistant Professor, Department of Anesthesiology, State University of New York Upstate Medical Center. †Associate Professor, Department of Anesthesiology, Thomas Jefferson University Hospital. ‡Chief of Cardiothoracic Surgery and Associate Professor of Surgery, State University of New York Upstate Medical Center. §Director, Department of Thoracic Surgery, Mt. Sinai Hospital. Departments of Anesthesiology, Cardiothoracic Surgery, and Surgery, State University of New York Upstate Medical Center, Syracuse, New York; Department of Anesthesiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; and Department of Thoracic Surgery, Mt. Sinai Hospital, Cleveland, Ohio. Reprint requests to Dr. Gerson, Department of Anesthesiology, SUNY Upstate Medical Center, 750 East Adams Street, Syracuse, NY 13210. Accepted for publication October 26, 1981. Free Abstract Whole-body arterial and venous dilating properties of nitroprusside and nitroglycerin were compared with each other in 20 adult patients during cardiopulmonary bypass for coronary artery bypass or valvular heart surgery and were compared with simultaneous forearm vascular measurements. Nitroprusside was found to be a more effective whole-body arterial vasodilator and nitroglycerin a better whole-body venous vasodilator when each drug was infused at rates of 1.5 and 2.0 μg/kg/min. No difference in whole-body vasodilation between the two drugs was found at 1.0 μg/kg/min. Forearm plethysmography did not distinguish between the two drugs at any dose level. © 1982 International Anesthesia Research Society
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