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Author: Admin | 2025-04-28
Be similarly effective for people with type 2 diabetes, the two drugs are not equivalent, practically speaking, because Ozempic is available in more powerful dosages.Ozempic is additionally available in 1 and 2 mg doses. The maximum dose, when tested in people with type 2 diabetes using metformin, led to an A1C drop of 2.2 percentage points, and weight loss of 15 pounds. Rybelsus can’t match these results — at least not at the approved doses. Wegovy is available in an even higher dose, 2.4 mg per week.Higher Doses of Rybelsus Are on the WayIn the coming years, higher doses of Rybelsus may become available. In 2023, Novo Nordisk announced that it would seek FDA approval for larger doses of oral semaglutide for the treatment of type 2 diabetes.The PIONEER PLUS trial, which tested two experimental larger doses of oral semaglutide in people with type 2 diabetes, demonstrated that at the highest dose of 50 mg, the drug’s glucose-lowering and weight loss results were at least as good as those found in Ozempic 2 mg. Study participants had an A1C reduction of 2 percentage points, and weight loss of about 20 pounds.Is Rybelsus Approved for Weight Loss?Oral semaglutide is not yet approved as a weight loss therapy.In the recent OASIS 1 trial, however, researchers tested the effect of a 50 mg dose of oral semaglutide for people who were overweight or had obesity. After using the drug for over one year, study participants lost an average of 15.1 percent of their total body weight. That amount of weight loss was about equal to that achieved by people using the maximum dose of injectable semaglutide, suggesting that an oral semaglutide weight loss pill could be just as effective as the injectable.Novo Nordisk has already applied for regulatory approval for a semaglutide weight loss pill in both the United States and Europe.In the meantime, some doctors are prescribing Rybelsus off-label as a weight loss therapy for people without diabetes, especially those who cannot tolerate Wegovy or who are unable to use needles.How to Take RybelsusIf there’s another reason that Rybelsus hasn’t quite caught on, it’s that taking the drug is arguably something of a hassle.According to the instructions on the FDA label, you need to take Rybelsus on an empty stomach, every morning, 30 minutes before eating, drinking, or using any other oral medications. You may have up to 4 ounces of plain
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