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Author: Admin | 2025-04-28
Resulting insomnia.Amphetamine products should not be substituted on a mg-per-mg basis because of differing salt compositions and differing pharmacokinetic profiles; see dosage adjustment section for guidance on switching.Use: As part of a total treatment program for Attention Deficit Hyperactivity Disorder (ADHD).Renal Dose AdjustmentsUse with cautionLiver Dose AdjustmentsUse with cautionDose AdjustmentsElderly: Dose selection should be conservative starting at the low end of the dosing range and titrating slowlySWITCHING FROM OTHER AMPHETAMINE PRODUCTS:Do not substitute on a mg-per-mg basisWhen switching from one amphetamine product to another, discontinue current treatment, and titrate new formulation using the titration schedule in the Usual Dosage SectionSwitching from Evekeo immediate-release tablets to Evekeo ODT can be done on a mg-per-mg basisDose equivalents of Adzenys XR oral suspension and ODTs to Adderall XR extended-release capsules (mixed salts of a single-entity amphetamine)Adzenys ER and XR 3.1 mg equivalent to Adderall XR 5 mgAdzenys ER and XR 6.3 mg equivalent to Adderall XR 10 mgAdzenys ER and XR 9.4 mg equivalent to Adderall XR 15 mgAdzenys ER and XR 12.5 mg equivalent to Adderall XR 20 mgAdzenys ER and XR 15.7 mg equivalent to Adderall XR 25 mgAdzenys ER and XR 18.8 mg equivalent to Adderall XR 30 mgDose Modifications Due to Drug Interactions:Agents that alter urinary pH can impact urinary excretion and alter blood levels of amphetamine; acidifying agents decrease blood levels of amphetamines, while alkalinizing agents may increase blood level of amphetamines; adjust amphetamine dose accordinglyPrecautionsUS BOXED WARNINGS: ABUSE AND DEPENDENCEAmphetamines have a high potential for abuse; administration for prolonged periods of time may lead to drug dependence and must be avoided. Particular attention should be paid to the possibility of obtaining this drug for non-therapeutic use or distribution to others, and therefore, these drugs should be prescribed or dispensed sparingly. Misuse of amphetamine may cause sudden death
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