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Author: Admin | 2025-04-28
Mg twice daily.Efficacy of bupropion hydrochloride conventional tablets beyond 6 weeks not established systematically in controlled studies.Periodically reevaluate usefulness and appropriate dosage of drug in patients receiving prolonged therapy with conventional or extended-release tablets. Therapy with Conventional Bupropion Hydrochloride TabletsOralInitially, 100 mg twice daily. Alternatively, dosage may be initiated at 75 mg 3 times daily. To minimize risk of seizures, do not increase dosage by >100 mg daily every 3 days. If clinical improvement not apparent after >3 days, may increase to 100 mg 3 times daily. Dosages >300 mg should not be considered until completion of several weeks of therapy; if no improvement is apparent, then the dosage may be increased to a maximum of 150 mg 3 times daily.Therapy with Extended-release Bupropion Hydrochloride TabletsOralExtended-release, film-coated tablets (e.g., Wellbutrin SR): Initially, 150 mg once daily in the morning. If tolerated, may increase to target dosage of 150 mg twice daily (with ≥8 hours between doses) as early as fourth day of therapy. Dosages >300 mg daily should not be considered until completion of several weeks of therapy; then, if no apparent improvement, may increase dosage to maximum of 200 mg twice daily (with ≥8 hours between doses).Extended-release tablets (Wellbutrin XL): Initially, 150 mg once daily. If tolerated, may increase to target dosage of 300 mg once daily after 4 days of therapy.When switching from conventional or extended-release, film-coated tablets (e.g., Wellbutrin SR) to extended-release tablets (Wellbutrin XL), administer same total daily dose when possible.Extended-release 450-mg tablets (Forfivo XL) in patients who have received bupropion hydrochloride 300 mg daily for ≥2 weeks and require a dosage of 450 mg daily, or in patients currently receiving bupropion hydrochloride 450 mg daily: 450 mg once daily.When discontinuing therapy with Forfivo XL, use another bupropion formulation to taper the dose prior to discontinuance
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